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http://gsea4gwas.psych.ac.cn/getResult.do?result=5C6DD137E0D4FEC9DE5C9283428D1F48_1340814051756

503,445 variants input; 242,729 variants used; 15,976 genes mapped; 903 gene sets selected; 48 results.

Pathways/gene sets with FDR<0.25 are regarded as to be possibly associated with traits; FDR<0.05 are regarded as high confidence or with statistical significance.
Pathway/Gene set name Description Manhattan plot P-value FDR Significant genes/Selected genes/All genes
hsa00970 hsa00970 More... < 0.001 0.0020 16/34/470
Genes annotated by t...... Genes annotated by the GO term GO:0045765. Any process that modulates the frequency, rate or extent of angiogenesis. More... < 0.001 0.03425 10/21/26
hsa00030 hsa00030 More... < 0.001 0.040400002 9/20/470
Genes annotated by t...... Genes annotated by the GO term GO:0007417. The process whose specific outcome is the progression of the central nervous system over time, from its formation to the mature structure. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain, spinal cord and spinal nerves. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord. More... < 0.001 0.040666666 51/97/122
Genes annotated by t...... Genes annotated by the GO term GO:0005178. Interacting selectively with an integrin. More... < 0.001 0.059833333 16/25/30
Genes annotated by t...... Genes annotated by the GO term GO:0051348. Any process that stops or reduces the rate of transferase activity, the catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from a donor compound to an acceptor. More... < 0.001 0.061 11/29/35
Genes annotated by t...... Genes annotated by the GO term GO:0051093. Any process that stops, prevents or reduces the rate or extent of development, the biological process whose specific outcome is the progression of an organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult). More... < 0.001 0.077285714 52/168/193
CXCR4 Signaling Path...... CXCR4 Signaling Pathway More... 0.0030 0.16769566 13/23/24
Genes annotated by t...... Genes annotated by the GO term GO:0046930. Any small opening in a membrane that allows the passage of gases and/or liquids. More... 0.0060 0.17077273 10/33/34
Genes annotated by t...... Genes annotated by the GO term GO:0006302. The repair of double-strand breaks in DNA via homologous and nonhomologous mechanisms to reform a continuous DNA helix. More... 0.0080 0.17137499 8/20/22
Genes annotated by t...... Genes annotated by the GO term GO:0051338. Any process that modulates the frequency, rate or extent of transferase activity, the catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. More... 0.0030 0.17273684 41/139/157
hsa00480 hsa00480 More... 0.012 0.17325 10/38/470
Genes annotated by t...... Genes annotated by the GO term GO:0004879. A ligand-dependent receptor found in the nucleus of the cell. More... 0.0030 0.17445001 12/24/25
Genes annotated by t...... Genes annotated by the GO term GO:0043086. Any process that stops or reduces the activity of an enzyme. More... 0.0050 0.17684 19/56/69
Genes annotated by t...... Genes annotated by the GO term GO:0003704. Functions to enable the transcription of specific, or specific sets, of genes by RNA polymerase II. More... 0.0040 0.17823529 10/30/35
Genes annotated by t...... Genes annotated by the GO term GO:0032403. Interacting selectively with any protein complex (a complex of two or more proteins that may include other nonprotein molecules). More... 0.0030 0.17842858 22/47/54
Genes annotated by t...... Genes annotated by the GO term GO:0044453. Any constituent part of the nuclear membrane, the envelope that surrounds the nucleus of eukaryotic cells. More... 0.0080 0.18094444 11/38/40
hsa00010 hsa00010 More... 0.0070 0.18178572 16/52/470
Genes annotated by t...... Genes annotated by the GO term GO:0003823. Interacting selectively with an antigen, any substance which is capable of inducing a specific immune response and of reacting with the products of that response, the specific antibody or specifically sensitized T-lymphocytes, or both. Binding may counteract the biological activity of the antigen. More... 0.0030 0.1822 9/21/28
Genes annotated by t...... Genes annotated by the GO term GO:0000793. A highly compacted molecule of DNA and associated proteins resulting in a cytologically distinct structure. More... 0.0090 0.18337038 11/27/33
Genes annotated by t...... Genes annotated by the GO term GO:0045859. Any process that modulates the frequency, rate or extent of protein kinase activity. More... 0.0050 0.1842069 39/133/151
Genes annotated by t...... Genes annotated by the GO term GO:0019748. The chemical reactions and pathways resulting in many of the chemical changes of compounds that are not necessarily required for growth and maintenance of cells, and are often unique to a taxon. In multicellular organisms secondary metabolism is generally carried out in specific cell types, and may be useful for the organism as a whole. In unicellular organisms, secondary metabolism is often used for the production of antibiotics or for the utilization and acquisition of unusual nutrients. More... 0.0090 0.18607691 9/23/25
Genes annotated by t...... Genes annotated by the GO term GO:0007059. The process by which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets. More... 0.0090 0.1860909 10/30/31
Genes annotated by t...... Genes annotated by the GO term GO:0031667. A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of nutrients. More... 0.011 0.18638462 8/27/29
Genes annotated by t...... Genes annotated by the GO term GO:0006916. A process which directly inhibits any of the steps required for cell death by apoptosis. More... 0.0030 0.19157143 29/103/115
Genes annotated by t...... Genes annotated by the GO term GO:0043549. Any process that modulates the frequency, rate or extent of kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. More... 0.0070 0.1945 39/135/153
Genes annotated by t...... Genes annotated by the GO term GO:0009991. A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an extracellular stimulus. More... 0.0060 0.19716667 9/30/33
Genes annotated by t...... Genes annotated by the GO term GO:0005829. That part of the cytoplasm that does not contain membranous or particulate subcellular components. More... 0.0020 0.20269999 58/174/202
Genes annotated by t...... Genes annotated by the GO term GO:0043069. Any process that stops, prevents or reduces the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes. More... 0.0020 0.2043871 34/131/148
Genes annotated by t...... Genes annotated by the GO term GO:0005525. Interacting selectively with GTP, guanosine triphosphate. More... 0.012 0.21697222 11/39/46
hsa01040 hsa01040 More... 0.0030 0.217 10/21/470
hsa04920 hsa04920 More... 0.0090 0.21777144 25/67/470
PKC-catalyzed phosph...... PKC-catalyzed phosphorylation of inhibitory phosphoprotein of myosin phosphatase More... 0.0030 0.21900001 15/28/31
hsa05322 hsa05322 More... 0.0080 0.22021052 18/50/470
Genes annotated by t...... Genes annotated by the GO term GO:0043066. Any process that stops, prevents or reduces the frequency, rate or extent of cell death by apoptosis. More... 0.0050 0.22332352 34/130/147
Thrombin signaling a...... Thrombin signaling and protease-activated receptors More... 0.0030 0.22378378 18/34/37
Genes annotated by t...... Genes annotated by the GO term GO:0017016. Interacting selectively with any member of the Ras superfamily of monomeric GTPases. More... 0.014 0.22385105 9/22/24
Genes annotated by t...... Genes annotated by the GO term GO:0005635. The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space). More... 0.0060 0.22396874 20/65/70
Genes annotated by t...... Genes annotated by the GO term GO:0008277. Any process that modulates the frequency, rate or extent of G-protein coupled receptor protein signaling pathway activity. More... 0.0040 0.22455555 10/20/23
Genes annotated by t...... Genes annotated by the GO term GO:0019901. Interacting selectively with a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate. More... 0.0090 0.22547826 20/56/62
Genes annotated by t...... Genes annotated by the GO term GO:0007420. The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. The brain is one of the two components of the central nervous system and is the center of thought and emotion. It is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.). More... 0.011 0.22737779 20/39/51
    TRANSFERASE ACTIVITY TRANSFERRING ALKYL OR ARYLOTHER THAN METHYLGROUPS
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Genes annotated by t...... Genes annotated by the GO term GO:0016765. Catalysis of the transfer of an alkyl or aryl (but not methyl) group from one compound (donor) to another (acceptor). More... 0.014 0.22867501 8/24/30
hsa01510 hsa01510 More... 0.01 0.22893181 14/40/470
Genes annotated by t...... Genes annotated by the GO term GO:0051082. Interacting selectively with an unfolded protein. More... 0.014 0.22930768 9/38/41
Genes annotated by t...... Genes annotated by the GO term GO:0030695. Modulates the rate of GTP hydrolysis by a GTPase. More... 0.0070 0.22995123 46/102/117
Genes annotated by t...... Genes annotated by the GO term GO:0012505. A collection of membranous structures involved in transport within the cell. The main components of the endomembrane system are endoplasmic reticulum, Golgi bodies, vesicles, cell membrane and nuclear envelope. Members of the endomembrane system pass materials through each other or though the use of vesicles. More... 0.0060 0.23130953 57/189/212
Genes annotated by t...... Genes annotated by the GO term GO:0007565. The physiological processes that allow an embryo or foetus to develop within the body of a female animal. It covers the time from fertilization of a female ovum by a male spermatozoon until birth. More... 0.0080 0.23193751 13/34/52
Genes annotated by t...... Genes annotated by the GO term GO:0030036. A process that is carried out at the cellular level which results in the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins. More... 0.0080 0.23244186 36/90/104

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Last update: June 23, 2010