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http://gsea4gwas.psych.ac.cn/getResult.do?result=6463C2C39F31A524B51A58833DF49B70_1352697088992

728,218 variants input; 324,174 variants used; 16,548 genes mapped; 926 gene sets selected; 104 results.

Pathways/gene sets with FDR<0.25 are regarded as to be possibly associated with traits; FDR<0.05 are regarded as high confidence or with statistical significance.
Pathway/Gene set name Description Manhattan plot P-value FDR Significant genes/Selected genes/All genes
Genes annotated by t...... Genes annotated by the GO term GO:0005267. Catalysis of facilitated diffusion of a potassium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. More... < 0.001 0.0045 27/46/50
Genes annotated by t...... Genes annotated by the GO term GO:0008324. Catalysis of the transfer of cation from one side of the membrane to the other. More... < 0.001 0.004666667 90/194/211
Genes annotated by t...... Genes annotated by the GO term GO:0008076. A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential. More... < 0.001 0.0090 23/38/40
Genes annotated by t...... Genes annotated by the GO term GO:0022836. Catalysis of the transmembrane transfer of a solute by a channel that opens in response to a specific stimulus. More... < 0.001 0.0095 58/116/121
Genes annotated by t...... Genes annotated by the GO term GO:0005261. Catalysis of the energy-independent passage of cations across a lipid bilayer down a concentration gradient. More... < 0.001 0.0118 56/111/118
Genes annotated by t...... Genes annotated by the GO term GO:0006813. The directed movement of potassium ions (K+) into, out of, within or between cells. More... < 0.001 0.0125 28/54/58
Genes annotated by t...... Genes annotated by the GO term GO:0005216. Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. More... < 0.001 0.013428571 65/138/147
hsa04330 hsa04330 More... < 0.001 0.0135 18/36/470
Genes annotated by t...... Genes annotated by the GO term GO:0005249. Catalysis of the transmembrane transfer of a potassium ion by a voltage-gated channel. More... < 0.001 0.018111112 19/35/36
hsa00860 hsa00860 More... < 0.001 0.022416666 18/39/470
Genes annotated by t...... Genes annotated by the GO term GO:0022838. Catalysis of energy-independent facilitated diffusion, mediated by passage of a specific solute through a transmembrane aqueous pore or channel. Stereospecificity is not exhibited but this transport may be specific for a particular molecular species or class of molecules. More... < 0.001 0.0228 66/144/154
Genes annotated by t...... Genes annotated by the GO term GO:0005764. Any of a group of related cytoplasmic, membrane bound organelles that are found in most animal cells and that contain a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions. More... < 0.001 0.023142857 22/53/60
Genes annotated by t...... Genes annotated by the GO term GO:0000323. A vacuole that is maintained at an acidic pH and which contains degradative enzymes, including a wide variety of acid hydrolases. More... < 0.001 0.023142857 22/53/60
hsa00830 hsa00830 More... 0.0010 0.023363637 23/57/470
Genes annotated by t...... Genes annotated by the GO term GO:0015293. Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. More... < 0.001 0.026294118 15/28/31
Genes annotated by t...... Genes annotated by the GO term GO:0015672. The directed movement of inorganic cations with a valency of one into, out of, within or between cells. Inorganic cations are atoms or small molecules with a positive charge which do not contain carbon in covalent linkage. More... < 0.001 0.026466668 39/84/93
Genes annotated by t...... Genes annotated by the GO term GO:0006812. The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells. More... < 0.001 0.02647619 60/133/146
Genes annotated by t...... Genes annotated by the GO term GO:0046873. Catalysis of the transfer of metal ions from one side of a membrane to the other. More... < 0.001 0.026636364 64/136/145
Genes annotated by t...... Genes annotated by the GO term GO:0003743. Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide. More... 0.0010 0.0269375 8/23/24
Genes annotated by t...... Genes annotated by the GO term GO:0015457. Facilitates transport across one or more biological membranes but do not themselves participate directly in transport. These proteins always function in conjunction with one or more established transport systems. They may provide a function connected with energy coupling to transport, play a structural role in complex formation, serve a biogenic or stability function or function in regulation. More... 0.0010 0.027649999 12/21/25
Genes annotated by t...... Genes annotated by the GO term GO:0000904. The change in form (cell shape and size) that occurs when relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. More... < 0.001 0.028166668 26/44/49
Genes annotated by t...... Genes annotated by the GO term GO:0045202. The junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell; the site of interneuronal communication. As the nerve fiber approaches the synapse it enlarges into a specialized structure, the presynaptic nerve ending, which contains mitochondria and synaptic vesicles. At the tip of the nerve ending is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic nerve ending secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane. More... < 0.001 0.029 15/27/27
hsa04140 hsa04140 More... 0.0030 0.029869564 10/26/470
Genes annotated by t...... Genes annotated by the GO term GO:0006811. The directed movement of charged atoms or small charged molecules into, out of, within or between cells. More... < 0.001 0.029923078 71/166/184
Genes annotated by t...... Genes annotated by the GO term GO:0005773. A closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material. Cells contain one or several vacuoles, that may have different functions from each other. Vacuoles have a diverse array of functions. They can act as a storage organelle for nutrients or waste products, as a degradative compartment, as a cost-effective way of increasing cell size, and as a homeostatic regulator controlling both turgor pressure and pH of the cytosol. More... < 0.001 0.030333333 23/58/68
    HEMATOPOIETIN INTERFERON CLASSD200 DOMAIN CYTOKINE RECEPTOR BINDING
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Genes annotated by t...... Genes annotated by the GO term GO:0005126. More... 0.0060 0.03108 8/27/29
Genes annotated by t...... Genes annotated by the GO term GO:0030522. Any series of molecular signals initiated by a ligand entering the target cell, where it binds to an intracellular receptor. More... 0.0020 0.033133335 9/20/21
Genes annotated by t...... Genes annotated by the GO term GO:0031175. The process whose specific outcome is the progression of the neurite over time, from its formation to the mature structure. The neurite is any process extending from a neural cell, such as axons or dendrites. More... < 0.001 0.033857144 26/48/53
Genes annotated by t...... Genes annotated by the GO term GO:0016247. More... 0.0010 0.034172412 11/20/23
Genes annotated by t...... Genes annotated by the GO term GO:0022832. Catalysis of the transmembrane transfer of a solute by a channel whose open state is dependent on the voltage across the membrane in which it is embedded. More... < 0.001 0.034185186 35/70/73
Genes annotated by t...... Genes annotated by the GO term GO:0005125. Functions to control the survival, growth, differentiation and effector function of tissues and cells. More... 0.0010 0.041 27/98/111
hsa04720 hsa04720 More... < 0.001 0.044969697 33/65/470
Genes annotated by t...... Genes annotated by the GO term GO:0030001. The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells. More... 0.0010 0.04590625 48/105/116
Regulation of PGC-1a Regulation of PGC-1a More... < 0.001 0.046166666 12/21/26
Genes annotated by t...... Genes annotated by the GO term GO:0019208. Modulates the activity of a phosphatase, an enzyme which catalyzes of the removal of a phosphate group from a substrate molecule. More... 0.0010 0.04632353 12/22/26
Genes annotated by t...... Genes annotated by the GO term GO:0043235. Any protein group composed of two or more subunits, which may or may not be identical, which undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function. More... 0.0010 0.04742857 24/54/56
Genes annotated by t...... Genes annotated by the GO term GO:0004540. Catalysis of the hydrolysis of phosphodiester bonds in chains of RNA. More... 0.0050 0.06108108 7/24/25
hsa00590 hsa00590 More... 0.0050 0.06210526 17/47/470
hsa00500 hsa00500 More... 0.0010 0.06317073 30/70/470
Genes annotated by t...... Genes annotated by the GO term GO:0004497. Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. More... 0.0030 0.063700005 12/26/29
hsa00040 hsa00040 More... < 0.001 0.06371795 14/22/470
Genes annotated by t...... Genes annotated by the GO term GO:0048666. The process whose specific outcome is the progression of a neuron over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. More... 0.0010 0.06419048 28/56/61
Genes annotated by t...... Genes annotated by the GO term GO:0031589. The attachment of a cell to the underlying substrate via adhesion molecules. More... 0.0010 0.06704651 18/35/38
Genes annotated by t...... Genes annotated by the GO term GO:0000502. A large multisubunit complex which catalyzes protein degradation. This complex consists of the barrel shaped proteasome core complex and one or two associated proteins or complexes that act in regulating entry into or exit from the core. More... 0.01 0.07106383 6/21/23
Genes annotated by t...... Genes annotated by the GO term GO:0016192. The directed movement of substances, either within a vesicle or in the vesicle membrane, into, out of or within a cell. More... 0.0030 0.07106666 61/170/188
Genes annotated by t...... Genes annotated by the GO term GO:0022843. Catalysis of the transmembrane transfer of a cation by a voltage-gated channel. A cation is a positively charged ion. More... 0.0020 0.072152175 32/63/66
Genes annotated by t...... Genes annotated by the GO term GO:0007409. Generation of a long process of a neuron, that carries efferent (outgoing) action potentials from the cell body towards target cells. More... 0.0010 0.07243182 23/38/43
Genes annotated by t...... Genes annotated by the GO term GO:0022603. Any process that modulates the frequency, rate or extent of anatomical structure morphogenesis. More... 0.0010 0.0736875 12/23/24
Genes annotated by t...... Genes annotated by the GO term GO:0003735. The action of a molecule that contributes to the structural integrity of the ribosome. More... 0.01 0.075500004 10/52/80
Genes annotated by t...... Genes annotated by the GO term GO:0030182. The process whereby a relatively unspecialized cell acquires specialized features of a neuron. More... 0.0010 0.07641177 36/71/76
Genes annotated by t...... Genes annotated by the GO term GO:0004519. Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks. More... 0.0060 0.07682 8/22/25
Genes annotated by t...... Genes annotated by the GO term GO:0042742. Reactions triggered in response to the presence of a bacterium that act to protect the cell or organism. More... 0.0090 0.07730612 7/22/24
Genes annotated by t...... Genes annotated by the GO term GO:0048699. The process by which nerve cells are generated. This includes the production of neuroblasts and their differentiation into neurons. More... 0.0010 0.07984906 38/76/83
Genes annotated by t...... Genes annotated by the GO term GO:0007160. The binding of a cell to the extracellular matrix via adhesion molecules. More... 0.0030 0.08027778 17/34/37
hsa04020 hsa04020 More... 0.0040 0.09071428 72/157/470
Genes annotated by t...... Genes annotated by the GO term GO:0051128. Any process that modulates the frequency, rate or extent of the processes involved in the formation, arrangement of constituent parts, or disassembly of cell structures, including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope. More... 0.0070 0.09210909 43/115/123
Genes annotated by t...... Genes annotated by the GO term GO:0035257. Interacting selectively with a nuclear hormone receptor, a ligand-dependent receptor found in the nucleus of the cell. More... 0.0040 0.09389655 10/25/28
Genes annotated by t...... Genes annotated by the GO term GO:0051427. Interacting selectively with a receptor for hormones. More... 0.0030 0.09452631 10/26/29
hsa04512 hsa04512 More... 0.0030 0.09669492 42/81/470
Genes annotated by t...... Genes annotated by the GO term GO:0009100. The chemical reactions and pathways involving glycoproteins, any protein that contains covalently bound glycose (i.e. monosaccharide) residues other than as a moiety of nucleic acid; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide. More... 0.0050 0.09828333 32/76/88
Genes annotated by t...... Genes annotated by the GO term GO:0009101. The chemical reactions and pathways resulting in the formation of glycoproteins, any protein that contains covalently bound glycose (i.e. monosaccharide) residues other than as a moiety of nucleic acid; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide. More... 0.0030 0.10608197 28/63/73
hsa00983 hsa00983 More... 0.0020 0.10920968 20/45/470
Control of skeletal ...... Control of skeletal myogenesis by HDAC & calcium/calmodulin-dependent kinase (CaMK) More... 0.0050 0.11320312 14/27/32
Genes annotated by t...... Genes annotated by the GO term GO:0022834. Catalysis of the transmembrane transfer of a solute by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts. More... 0.0030 0.11352381 18/38/39
    Metabolism of xenobiotics by cytochrome P450
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hsa00980 hsa00980 More... 0.0060 0.11447692 24/64/470
VEGF, Hypoxia, and A...... VEGF, Hypoxia, and Angiogenesis More... 0.0060 0.11493939 11/27/29
Signaling Pathway fr...... Signaling Pathway from G-Protein Families More... 0.0040 0.11608955 16/33/37
Genes annotated by t...... Genes annotated by the GO term GO:0007169. The series of molecular signals generated as a consequence of a transmembrane receptor tyrosine kinase binding to its physiological ligand. More... 0.0040 0.12886764 35/79/82
Genes annotated by t...... Genes annotated by the GO term GO:0008509. Catalysis of the transfer of a negatively charged ion from one side of a membrane to the other. More... 0.0090 0.13599999 21/54/59
Genes annotated by t...... Genes annotated by the GO term GO:0007600. The series of events required for an organism to receive a sensory stimulus, convert it to a molecular signal, and recognize and characterize the signal. More... 0.0030 0.1406857 62/170/190
hsa00982 hsa00982 More... 0.0040 0.14256337 24/65/470
Genes annotated by t...... Genes annotated by the GO term GO:0007420. The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. The brain is one of the two components of the central nervous system and is the center of thought and emotion. It is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.). More... 0.011 0.14565279 22/43/51
Genes annotated by t...... Genes annotated by the GO term GO:0005840. An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. More... 0.025 0.14865753 9/34/39
Genes annotated by t...... Genes annotated by the GO term GO:0003704. Functions to enable the transcription of specific, or specific sets, of genes by RNA polymerase II. More... 0.012 0.1500946 11/32/35
hsa05110 hsa05110 More... 0.011 0.15012 21/57/470
Genes annotated by t...... Genes annotated by the GO term GO:0016705. Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor. More... 0.016 0.15239473 14/32/35
Genes annotated by t...... Genes annotated by the GO term GO:0022008. Generation of cells within the nervous system. More... 0.0060 0.15676624 40/86/93
Genes annotated by t...... Genes annotated by the GO term GO:0007517. The process whose specific outcome is the progression of the muscle over time, from its formation to the mature structure. The muscle is an organ consisting of a tissue made up of various elongated cells that are specialized to contract and thus to produce movement and mechanical work. More... 0.0060 0.16155128 34/85/92
Genes annotated by t...... Genes annotated by the GO term GO:0000775. The central region of a chromosome that includes the centromere and associated proteins. In monocentric chromosomes, this region corresponds to a single area of the chromosome, whereas in holocentric chromosomes, it is evenly distributed along the chromosome. More... 0.02 0.16410126 11/28/31
Genes annotated by t...... Genes annotated by the GO term GO:0005923. A belt-like region of very close contact between the plasma membranes of adjacent cells so that the intercellular space is completely occluded. They occur in epithelia and brain endothelia. More... 0.013 0.1660625 11/24/31
hsa00052 hsa00052 More... 0.01 0.17141975 11/24/470
Genes annotated by t...... Genes annotated by the GO term GO:0008066. Combining with glutamate to initiate a change in cell activity. More... 0.0060 0.17180488 13/20/20
Genes annotated by t...... Genes annotated by the GO term GO:0000122. Any process that stops, prevents or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter. More... 0.015 0.17775904 26/75/83
hsa04742 hsa04742 More... 0.0080 0.18384524 14/37/470
Genes annotated by t...... Genes annotated by the GO term GO:0005096. Increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP. More... 0.011 0.18979545 24/53/56
Insulin Signaling Pa...... Insulin Signaling Pathway More... 0.016 0.19159772 8/20/22
Genes annotated by t...... Genes annotated by the GO term GO:0003702. Functions to initiate or regulate RNA polymerase II transcription. More... 0.015 0.1923412 48/160/182
EGF Signaling Pathwa...... EGF Signaling Pathway More... 0.013 0.19338372 14/28/31
hsa03320 hsa03320 More... 0.025 0.19839561 21/64/470
Genes annotated by t...... Genes annotated by the GO term GO:0016481. Any process that stops, prevents or reduces the frequency, rate or extent of transcription. More... 0.015 0.1984719 53/165/185
Genes annotated by t...... Genes annotated by the GO term GO:0004518. Catalysis of the hydrolysis of ester linkages within nucleic acids. More... 0.019 0.19917779 13/47/54
hsa04612 hsa04612 More... 0.032 0.21077175 15/70/470
Genes annotated by t...... Genes annotated by the GO term GO:0042277. Interacting selectively with peptides, any of a group of organic compounds comprising two or more amino acids linked by peptide bonds. More... 0.018 0.22170967 22/74/82
Genes annotated by t...... Genes annotated by the GO term GO:0005798. Any vesicle associated with the Golgi complex and involved in mediating transport within the Golgi or between the Golgi and other parts of the cell. More... 0.021 0.22493684 9/25/27
Genes annotated by t...... Genes annotated by the GO term GO:0006898. The uptake of external materials by cells, utilizing receptors to ensure specificity of transport. A specific receptor on the cell surface binds tightly to the extracellular macromolecule (the ligand) that it recognizes; the plasma-membrane region containing the receptor-ligand complex then undergoes endocytosis, forming a transport vesicle containing the receptor-ligand complex and excluding most other plasma-membrane proteins. Receptor-mediated endocytosis generally occurs via clathrin-coated pits and vesicles. More... 0.022 0.22540425 10/27/33
Genes annotated by t...... Genes annotated by the GO term GO:0005581. Any of the various assemblies in which collagen chains form a left-handed triple helix; may assemble into higher order structures. More... 0.012 0.23076041 13/23/23
Genes annotated by t...... Genes annotated by the GO term GO:0016327. The apical end of the lateral plasma membrane of epithelial cells. More... 0.025 0.237 12/26/34
Genes annotated by t...... Genes annotated by the GO term GO:0043296. A functional unit located near the cell apex at the points of contact between epithelial cells, which in vertebrates is composed of the tight junction, the zonula adherens, and desmosomes and in invertebrates is composed of the subapical complex (SAC), the zonula adherens and the septate junction. Functions in the regulation of cell polarity, tissue integrity and intercellular adhesion and permeability. More... 0.025 0.237 12/26/34
Bioactive Peptide In...... Bioactive Peptide Induced Signaling Pathway More... 0.019 0.23954639 19/38/45
Genes annotated by t...... Genes annotated by the GO term GO:0009887. Morphogenesis of an organ. An organ is defined as a tissue or set of tissues that work together to perform a specific function or functions. Morphogenesis is the process by which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions. More... 0.023 0.2397449 47/134/144
Genes annotated by t...... Genes annotated by the GO term GO:0016337. The attachment of one cell to another cell via adhesion molecules. More... 0.027 0.24078788 32/79/86
hsa01032 hsa01032 More... 0.032 0.24082 9/24/470
Genes annotated by t...... Genes annotated by the GO term GO:0007005. A process that is carried out at the cellular level which results in the formation, arrangement of constituent parts, or disassembly of a mitochondrion; includes mitochondrial morphology and distribution, and replication of the mitochondrial genome as well as synthesis of new mitochondrial components. More... 0.033 0.24125244 11/40/48
Genes annotated by t...... Genes annotated by the GO term GO:0005694. A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. More... 0.035 0.24893335 28/109/123

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Last update: June 23, 2010