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Download your result file: Download Gene Set File     Download Manhattan Pictures Result File Format

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http://gsea4gwas.psych.ac.cn/getResult.do?result=9DA3BCD71BDB4CC5DEC84F64927C20EE.s3_1265892314763

518754 variants input; 479086 variants used; 16524 genes mapped; 251 gene sets selected; 23 results.

Pathways/gene sets with FDR<0.25 are regarded as to be possibly associated with traits; FDR<0.05 are regarded as high confidence or with statistical significance.
Pathway/Gene set name Description Manhattan plot P-value FDR Significant genes/Selected genes/All genes
Genes involved in an...... Genes involved in antigen processing and presentation More... < 0.001 0.0090 27/62/83
Interleukins and TNF...... Interleukins and TNF serve as signals to coordinate the inflammatory response, in which macrophages recruit and activate neutrophils, fibroblasts, and T cells. More... < 0.001 0.0095 16/28/29
Csk inhibits T-cell ...... Csk inhibits T-cell activation by phosphorylating Lck; Csk is regulated by cAMP-dependent kinases and is opposed by the T-cell activator CD45. More... < 0.001 0.0106666675 11/20/24
Cardiac myocytes hav...... Cardiac myocytes have a variety of adrenergic receptors that induce subtype-specific signaling effects. More... < 0.001 0.04 15/22/28
Genes involved in ri...... Genes involved in ribosome More... < 0.001 0.047 17/45/98
More... 0.0030 0.0765 11/22/26
Genes involved in PP...... Genes involved in PPAR signaling pathway More... 0.0010 0.082777776 29/63/70
Genes involved in ca...... Genes involved in calcium signaling pathway More... 0.0020 0.08457143 87/148/174
More... 0.0020 0.085 68/128/150
Genes involved in na...... Genes involved in natural killer cell mediated cytotoxicity More... 0.0050 0.095 49/114/132
More... 0.0030 0.09518182 34/55/75
Genes involved in ga...... Genes involved in gap junction More... 0.0040 0.09846154 44/84/98
More... 0.0040 0.099583335 71/137/184
Ras, Rac, and Rho co...... Ras, Rac, and Rho coordinate to induce cyclin D1 expression and activate cdk2 to promote the G1/S transition. More... 0.015 0.15973333 11/21/23
Genes involved in ni...... Genes involved in nitrogen metabolism More... 0.015 0.1991875 11/20/24
Bacterial lipopolysa...... Bacterial lipopolysaccharide activates AKT to promote the survival and activation of macrophages and inhibits Gsk3-beta to promote beta-catenin accumulation in the nucleus. More... 0.013 0.21364705 14/22/27
More... 0.024 0.21533333 14/35/40
Genes involved in in...... Genes involved in inositol phosphate metabolism More... 0.022 0.23544 19/40/51
CDK4/6-cyclin D and ...... CDK4/6-cyclin D and CDK2-cyclin E phosphorylate Rb, which allows the transcription of genes needed for the G1/S cell cycle transition. More... 0.027 0.237875 12/24/28
G-alpha-q activates ...... G-alpha-q activates phospholipase C, resulting in calcium influx and increasing protein kinase C activity. More... 0.014 0.24018182 12/25/28
More... 0.012 0.24434783 71/124/143
Genes involved in ty...... Genes involved in type II diabetes mellitus More... 0.018 0.24489473 20/42/44
Genes involved in ar...... Genes involved in arachidonic acid metabolism More... 0.025 0.24823809 21/46/54

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Last update: June 23, 2010